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The Rise of Fentanyl Overdoses in Philadelphia

Tips for Supporting Your Loved One in Recovery

The Dangers, Symptoms, and How to Get Help

June 11, 2025

Over the past decade, fentanyl has become a major driver of opioid-related deaths across the United States, with Philadelphia being hit especially hard. Once prescribed for the treatment of severe pain, fentanyl is now frequently manufactured illegally and mixed into street drugs, often without the users’ knowledge. 

According to the United States Drug Enforcement Administration, fentanyl is involved in almost 80% of Philadelphia's fatal overdoses, making it the most dangerous substance affecting the region. Its high potency, rapid onset, and presence in non-opioid drugs such as cocaine and counterfeit pills have created a public health crisis that is only continuing to grow.

With overdose rates continuing to climb, raising awareness about the risks, symptoms, and available treatment options is critical to saving lives. 

Fentanyl in Philadelphia: A Dangerous Shift in the Drug Supply

Illicit fentanyl is a synthetic opioid that is often produced in unregulated labs and sold on the street. Because of its low production cost and high potency, it is commonly mixed into heroin, cocaine, methamphetamine, and even pressed into pills that resemble prescription medications. 

In Philadelphia, this has led to a dramatic increase in unintentional overdoses. Many individuals who use substances recreationally or live with addiction may not realize that fentanyl is present in the drugs they are consuming. The result is a significant rise in both fatal and non-fatal overdoses, particularly in neighborhoods already struggling with substance use. 

Public health data confirms that fentanyl is now the leading cause of overdose deaths in the region, highlighting the urgent need for accessible fentanyl detox services in Philadelphia.

Identifying a Fentanyl Overdose: Key Symptoms to Watch For

Recognizing the symptoms of a fentanyl overdose can be the difference between life and death. Due to its strength and the speed at which it acts, a person can become unresponsive within minutes. The most common symptoms include:

  • Slow or shallow breathing
  • Loss of consciousness
  • Pale, blue, or cold skin
  • Pinpoint pupils
  • Limpness or inability to respond

One major factor contributing to the sharp rise in fentanyl-related overdoses is the presence of adulterants like xylazine and medetomidine ("tranq" and "rhino tranq"), which have very short half-lives. Those using experience withdrawal symptoms more quickly and more intensely, often prompting them to use higher doses of fentanyl than their bodies can tolerate in an attempt to avoid those symptoms.

In suspected cases, immediate emergency response is essential. Naloxone or Narcan, an opioid overdose reversal medication, can temporarily restore breathing and save a life if administered quickly. However, that has not always been the case in recent years.

According to Federico Ceppa, MD, today’s fentanyl overdoses have changed the landscape of emergency care in inpatient addiction treatment centers and rehabs. “We have had to educate front-line staff that one dose of Narcan is not necessarily sufficient to reverse the effects of opioids,” he said.

“Fentanyl is more potent than heroin and other opioids. The adulterants in the fentanyl bring on withdrawal symptoms faster and stronger. These two factors make fentanyl much more lethal. We have also had to change our detox protocols for both fentanyl and adulterants, using more intramuscular (IM) medications, benzodiazepines, and IV fluid.”

Widespread awareness of these signs and access to emergency interventions are critical as Philadelphia continues to confront record levels of fentanyl-related overdoses.

Fentanyl Withdrawal and the Importance of Medical Detox

Withdrawal from fentanyl can begin within hours of the last use and is often more intense than withdrawal from other opioids. The body quickly becomes dependent on the drug, leading to severe physical and psychological symptoms.

Symptoms of fentanyl withdrawal may include:

  • Muscle and bone pain
  • Nausea, vomiting, and diarrhea
  • Intense drug cravings
  • Anxiety, depression, and mood swings
  • Sleep disturbances and chills

The intensity of these symptoms often makes it difficult for individuals to stop using fentanyl without medical support. Detoxing without supervision can significantly increase the risk of relapse or serious health complications. A structured medical detox program offers the safest and most effective way to manage withdrawal and begin the recovery process.

Valley Forge Medical Center provides 24/7 medical supervision during the detoxification process. Many patients who inject fentanyl may also suffer from infections, abscesses, or other conditions requiring hospital-level wound care. In these cases, detox must be carefully managed alongside treatment for co-occurring medical issues.

Benefits of Inpatient Addiction Treatment

While detox addresses the immediate physical dependence on fentanyl, long-term recovery requires comprehensive behavioral health treatment. Inpatient addiction treatment offers a supportive and structured environment where individuals can begin to address the underlying causes of substance use. 

Programs at Valley Forge Medical Center offer individual and group therapy, medication-assisted treatment (MAT), psychiatric and dual diagnosis care, family counseling, and aftercare planning. 

Inpatient treatment is particularly beneficial for those who have experienced multiple relapses or who lack a stable home environment. It offers time and space to rebuild health, learn coping strategies, and establish a foundation for sustained sobriety. 

Getting Help for Fentanyl Addiction 

With the ongoing rise in fentanyl overdoses in Philadelphia, timely access to care is more important than ever. Individuals struggling with fentanyl use or concerned family members are encouraged to reach out for more information.

To learn more about inpatient rehab, fentanyl detox, or our other medical detox services, visit our website or contact our team directly at (610) 539-8500.